Although vitamin D is well known for promoting bone & teeth health and regulating vital calcium levels it does more than that. Since the COVID pandemic hit us in 2020, Vitamin D has been extensively recommended to support immunity. But very few explain how Vitamin D really acts in one's immunity, specially in the gut where great part of our immunity resides.
The mechanisms involved are fairly complex but can be :
- Gut epithelial cells and its associated immune cells express a particular Vitamin D receptor in their inner nucleus named Vitamin D Receptor or VDR
- These receptors are triggered by activated Vitamin D3, firing off certain genes
- Some of the associated genes are related to immunity and cell division:
- Tight Junctions proteins, that act as glue between cells that holds them together preventing leakage
Host Defense Peptides, that are small bioactive compounds that help control undesirable microbes
- Published science describes how butyrate increases the expression of cellular VDRs and its biding ability, enhancing exponentially the efficiency of Vitamin D3.
- This combination may safely support the normal functioning of immunity, barrier-function while supporting friendly microbiota in the gut.
* Vitamin D contributes to the normal function of the immune system.
** Vitamin D has a role in the process of cell division
Source of claims: Commission Regulation (EU) No 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children’s development and health.